Tadalafil

I-CMOAPI inoluhlu olupheleleyo lwezinto ezibunjiweyo zeTadalafil, kwaye inolawulo olupheleleyo lwenkqubo.Also yadlula i-GMP kunye nesiqinisekiso se-DMF.

Ebonisa zonke iziphumo 3

Yintoni iTadalafil

I-Tadalafil sisiyobisi esinyangiweyo esisetyenziselwa ukunyanga ukungasebenzi kakuhle kwe-erectile (ED) kunye neempawu ze-Prostate eyandisiweyo emadodeni. Kukwabonakalisiwe ukunyanga uxinzelelo lwegazi kwimiphunga (PAH).
I-Tadalafil (Inombolo ye-CAS: 171596-29-5) ifumaneka ngohlobo lwethebhulethi yomlomo okanye i-tadalafil powder kwaye ithengiswa ikakhulu phantsi kwegama leCialis (ye-erectile dysfunction okanye i-benign prostate enlargement) okanye i-Adcirca (ye-pulmonary arterial hypertension). I-Tadalafil ikwafumaneka ngohlobo lwayo oluqhelekileyo olungenakuba nawo onke amandla njengokwenza okokuqala


Isebenza njani i-tadalafil?

I-Tadalafil yenye ye-phosphodiesterase yohlobo lwe-5 (PDE5) inhibitors. Xa la maqela amachiza ethintela i-PDE5, nawo aya kuphucula ukusebenza kwe-erectile.
Ngexesha lokuvuselela inkanuko yesini, ulwakhiwo lwenzeka xa kukho ukuhamba kwegazi okwaneleyo kwimithambo ye-penile ekhokelela kwimithambo ekhululekile kunye nesihlunu esigudileyo se-corpus cavernosum. Le mpendulo imodareyithwa yimveliso ye-nitric oxide (NO) kwiiseli ze-endothelial kunye neeterminal terminals. Ukukhutshwa kwe-NO kukonyusa ukudityaniswa kwe-cyclic guanosine monophosphate (eyaziwa ngokuba yi-cyclic GMP okanye i-cGMP) kwiiseli zemisipha egudileyo. I-cyclic GMP inceda ukukhulula izihlunu ezigudileyo kunye nokunyusa ukuhamba kwegazi kwi-corpus cavernosum.
I-Tadalafil inqanda uhlobo lwe-phosphodiesterase yohlobo lwe-5 (PDE5) ngokwandisa inani le-cGMP. Kubalulekile ukuba uqaphele ukuba umntu kufuneka afumane ukuvuselelwa ngokwesini ukuze aqalise ukukhutshwa kwendalo kwe-nitric oxide. Kungenxa yokuba iimpembelelo zeTadalafil azizukwenzeka ngaphandle kokuvuselelwa ngokwesondo.
I-Tadalafil inokuzinciphisa iimpawu zedlala leprostate eyandisiweyo kubandakanya ukungxamiseka / ukuchama rhoqo, ubunzima bokuchama kunye nokungahambi kakuhle komchamo. Kufezekisa oku ngokuphumla kwezihlunu zeprotrate nakwisinyi.
Kwi-pulmonary hypertension, i-tadalafil inceda ukukhulula imithambo yegazi esifubeni. Oku kunceda ukwandisa ukubonelelwa kwegazi emiphungeni kwaye kunciphisa nomthwalo wentliziyo.


Abaphakathi beTadalafil

Kwinkqubo yokuvelisa i-tadalafil (i-CAS 151596-29-5), abanye abalamli bayenziwa. Ezinye iinkampani ziya kusebenzisa i-tadalafil intermediates ukuvelisa i-tadalafil.

I-171596-29-5

I-Tadalafil (i-CAS 171596-29-5) sisiyobisi esinamandla nesisebenzayo sokunyanga ukungasebenzi kakuhle kwe-erectile kunye nokwandiswa kwe-prostatic yokwanda emadodeni kunye ne-pulmonary arteries hypertension.

I-171489-59-1

ICas 171489-59-1 ikwabizwa ngokuba yiChloropretadalafil iphakathi kwimveliso yeTadalafil esetyenziselwa unyango lwe-erectile dysfunction. I-CAS 171489-59-1 inefomula yemolekyuli C22H19ClN2O5 enobunzima beemolekyuli ze-426.85 g / mol. Ifumaneka ngohlobo lokuqina okumhlophe.

I-171752-68-4

I-CAS 171752-68-4 eneemolekyuli zefomula eyi-C20H18N2O4.HCl kunye nobunzima beemolekyuli ze-386.83 g / mol nayo iphakathi tadalafil.
Baninzi abathengisi beetadalafil eziphakathi ezinikezela ngeetadalafil eziphakathi ezithengiswayo ngamaxabiso aphantsi. Nangona kunjalo, xa ucinga i-tadalafil yithenge kwiinkampani ezithembakeleyo ukuqinisekisa ukuba umgangatho awubandakanyi.
I-CMOAPI ngomnye wabathengisi abaphakathi be-tadalafil abaqinisekisa umgangatho ophakamileyo kunye namaxabiso okhuphiswano kwiimveliso zabo.


Ngubani kunye nendlela yokusebenzisa i-tadalafil

I-Tadalafil powder inganyanga oku kulandelayo emadodeni?

Ukungasebenzi kwe-Erectile

Ukungasebenzi kakuhle kwe-Erectile (i-ED) ekwabizwa ngokuba kukungabi namandla kuyimeko yamadoda apho angakwaziyo ukufumana okanye ukugcina ulwakhiwo ixesha elaneleyo lokuzibandakanya kwimicimbi yesondo. Ihlala ikhokelela kumdla kwezesondo kwaye inokubangela nezinye iingxaki ezinje ngaphambi kwexesha okanye ukulibaziseka ukunyuka kwaye ngamanye amaxesha ukungakwazi ukufikelela kwi-orgasm.
I-ED inokubangelwa zizizathu ezininzi zombini imeko yomzimba kunye neemvakalelo ezinje ngezifo ezithile ezinje ngesifo seswekile, isifo sentliziyo, kunye noxinzelelo lwegazi, ubudala, uxinzelelo, okanye ulwalamano.
I-Tadalafil inceda ukunyanga i-ED ngokwandisa ukuhamba kwegazi ukuya kwilungu lobudoda. Oku kunceda ukufezekisa kunye nokugcina ulwakhiwo. Nangona kunjalo, i-tadalafil inceda kuphela kulwakhiwo xa umntu sele evuselelekile ngokwesondo.

I-Benign prostatic hyperplasia (BPH)

Ikwabizwa ngokuba kukwandiswa kwe-prostate gland, i-BPH yimeko eqhelekileyo ehlala ifunyanwa emadodeni ebudaleni babo. Nangona kunjalo, ezinye izinto zinokukhokelela ekwandisweni kweprotate kubandakanya isifo seswekile kunye nokuphazamiseka kwentliziyo, indlela yokuphila, ngakumbi ukutyeba kunye nembali yosapho ye-BPH. Xa iprotrate ikhula inokubangela iimeko zokuchama.
Iimpawu ezinxulunyaniswa ne-Prostate gland eyandisiweyo yile, engxamisekileyo kunye nokuhlala urhalela ukukhupha umchamo, ukuba nzima ukuqala ukuchama, umjelo womchamo obuthathaka, okanye ukungakwazi ukukhupha isinyi ngokupheleleyo. Eminye imiqondiso ye-BPH inokubandakanya usulelo lwe-urinary tract (UTI), ukungakwazi ukuchama, okanye igazi kumchamo.
I-Tadalafil powder okanye ithebhulethi inceda ukuphumla imisipha kwiprostate nakwisinyi. Oku kunceda ukukhulula iimpawu ze-BPH.

I-pulmonary arteries hypertension (PAH)

I-PAH yimeko apho kukho uxinzelelo lwegazi oluphezulu kwimithambo ehambisa igazi kwimiphunga. Yahlukile kuxinzelelo lwegazi oluqhelekileyo. Kwenzeka xa imithambo yegazi esuka entliziyweni iye emiphungeni iba mxinwa okanye ivalekile.
Ezona mpawu zibalulekileyo zibandakanya iintlungu esifubeni, ukudinwa, okanye nokudumba emilenzeni nasezilindini.
I-Tadalafil inokunceda ekunciphiseni iimpawu ze-PAH ngokuphumla kwimithambo yegazi emiphungeni eyonyusa ngokulandelelana ukuhamba kwegazi.

Ungayisebenzisa njani i-tadalafil?

Idosi ye-tadalafil ixhomekeke kubudala bakho, ukusetyenziswa okucetywayo, kunye nayo nayiphi na eminye imiba yezonyango.
Ukusetyenziswa kweTadalafil akukhuthazwa kubantwana abangaphantsi kweminyaka yobudala be-18 ngelixa abaneminyaka engaphaya kwe-65 kufanelekile ukuba balumke kuba imizimba yabo ithatha ixesha elide ukufumana la machiza.
Kukho izikhokelo ezicacileyo zendlela yokusebenzisa i-tadalafil powder kodwa eyona fomu ixhaphakileyo yithebhulethi ye-tadalafil phantsi kwamagama eempawu ezahlukeneyo.
Kuyacetyiswa ukuba uthathe i-tadalafil kube kanye yonke imihla kwaye uyithathe malunga nexesha elifanayo yonke imihla ukufumana izibonelelo ze-tadalafil.
Idosi ye-tadalafil yokusetyenziswa ngeendlela ezahlukeneyo ichaziwe;
Ukungasebenzi kakuhle kwe-erectile, idosi ye-2.5-5 mg ithathwa yonke imihla okanye i-10 mg xa ithathwa kube kanye ngokwesidingo ngasinye.
Kwi-benign prostatic hyperplasia, idosi ye-5 mg ethathwa yonke imihla iyacetyiswa. I-Tadalafil kufuneka ithathwe kanye yonke imihla.
Xa ujongene neemeko zombini (ukungasebenzi kakuhle kwe-erectile kunye nokwandiswa kweprostate) idosi ye-5 mg ngosuku kufanelekile.
Ngxinzelelo lwegazi lwe-pulmonary arterial, idosi ye-tadalafil ye-40 mg ethathwa yonke imihla iyacetyiswa.
Njengazo zonke iziyobisi, into esebenzayo komnye ayinakwenza okufanayo komnye. Ezinye iindlela zeTadalafil zikhona. Nangona kunjalo, eyona nto intle ukuyenza kukuthetha nogqirha wakho malunga nezinye iindlela ezikhoyo ze-tadalafil kwaye ubone ukuba zeziphi ezifanelekileyo. Unokucetyiswa ukuba uthathe ezinye i-tadalafil ukuba uxabisa i-tadalafil okanye ngenxa yezinye izizathu.
Luxanduva lwakho ukuqaphela ukuba yintoni esebenzayo kakuhle kuwe ngelixa ulawula ukuba i-tadalafil lukhetho okanye iziphumo zecala ze-tadalafil zisuse izibonelelo ze-tadalafil.


Yintoni umahluko phakathi kweTadalafil kunye namanye amayeza okungasebenzi kakuhle kwe-erectile

ICialis (iTadalafil)

I-Cialis lunyango lonyango kwiklasi yeziyobisi ebizwa ngokuba yiPhosphodiesterase-5 Enzyme Inhibitors. Isetyenziselwa ukunyanga iimpawu zokungasebenzi kakuhle emzimbeni. Ingasetyenziselwa yodwa okanye iqokelelwe kunye nezinye iziyobisi.

I-Dapoxetine Hydrochloride

I-Dapoxetine hydrochloride ihlelwa njenge-serotonin reuptake inhibitors (SSRIs) ekhawulezayo.
I-Dapoxetine hydrochloride sisiyobisi esibhalisiweyo esisetyenziselwa ukunyanga ukuphuma kwangaphambi kwexesha. Ukuphuma ngaphambi kwexesha yimeko exhaphakileyo emadodeni ebandakanya ukungakwazi ukulibazisa ukunyuka. Olu luphawu olunye lokungasebenzi kakuhle kwamadoda.
Nangona zombini i-tadalafil kunye ne-dapoxetine hydrochloride zisetyenziselwa ukunyanga iimpawu ze-erectile dysfunction, enye i-tadalafil yi-phosphodiesterase inhibitor ngelixa enye, i-dapoxetine, ikhetha i-serotonin reuptake inhibitor.

IVardenafil Hydrochloride

IVardenafil liyeza kwiqela lamachiza abizwa ngokuba yi-phosphodiesterase (PDE) inhibitors. Isetyenziselwa ukunyanga ukungasebenzi kakuhle kwamadoda. Xa indoda ivuswa ngokwesondo, i-vardenafil yonyusa ukuhamba kwegazi ukuya kwilungu lobudoda eliqinisekisa ukuba ufumana ulwakhiwo.
IVardenafil ethengiswe phantsi kwegama lophawu lweLevitra lukhetha kakhulu kune-sildenafil kunye ne-tadalafil (Cialis) kwi-PDE5. Oku kuthetha ukuba idosi esezantsi ye-vardenafil iyafuneka ngeziphumo ebezingalindelekanga ezimbalwa ezinokubakho.
Omnye umahluko obonakalayo kwisiqingatha sobomi apho i-vardenafil (i-Levitra) ine-half-life ye-4-6 iiyure ngelixa i-tadalafil (Cialis) ine-half-life ye-17.5 iiyure. Oku kuthetha ukuba iTadalafil (Cialis) isebenza ixesha elide kune-vardenafil.

Avanafil

I-Avanafil sisiyobisi kwiqela le-phosphodiesterase inhibitors. Isetyenziselwa ukunyanga ukungasebenzi kakuhle kwe-erectile ngokuphucula ukuhamba kwegazi kwingingqi ye-penile.
Nangona zombini i-avanafil kunye ne-tadalafil ziyi-phosphodiesterase inhibitors, i-avanafil yeyona intsha kwaye inesiqingatha sobomi obufutshane malunga neeyure ezi-5 kune-tadalafil enobomi obunesiqingatha seyure eziyi-17.5.
Ukuqukumbela, i-tadalafil ilunge ngakumbi ngenxa yobomi bayo obude. Umntu unokuthatha iyeza ngokwenza iziphumo ebezingalindelekanga ezimbalwa ezinokwenzeka.


Iziphumo zecala leTadalafil kunye nezibonelelo

Izibonelelo zeTadalafil

Uninzi olujonga ukusebenzisa i-tadalafil powder ukuyithenga ngenxa yezona zibonelelo zayo eziphambili ze-tadalafil;

Ukunyanga ukungasebenzi kakuhle kwe-erectile

Ukwakhiwa kwePenile yinkqubo yokudibanisa imisebenzi yesondo. Ukungasebenzi kakuhle kwe-erectile kwenzeka xa indoda ingakwazi ukufumana kunye nokugcina ulwakhiwo. Oku kubangela imiba emininzi enje ngoxinzelelo, ukuzithemba okuphantsi, kunye neengxaki zobudlelwane.
Ukulungiswa kufezekiswa xa kukho ukuhamba kwegazi okwaneleyo kwilungu lobudoda. I-Tadalafil inceda ukukhulula iimpawu zokungasebenzi kakuhle ngokwandisa ukuhamba kwegazi ukuya kwilungu lobudoda.

Ukunyanga iimpawu ze-benign prostatic hyperplasia

I-Benign prostatic hyperplasia ikwabizwa ngokuba yi-prostate gland eyandisiweyo. Le yimeko eyenzeka ngokwendalo kunye nobudala. Xa i-prostate gland iyanda, iyancwina i-urethra. Ezinye zeempawu ezinxulunyaniswa neprostate eyandisiweyo zezi; Ukuchama okungxamisekileyo kunye nokuqhubekayo, kunzima ukuqala ukuchama, ukuchama kabuhlungu phakathi kwabanye.
I-Tadalafil iluncedo kumadoda aphethwe yi-benign prostatic hyperplasia ngokukhulula ezi mpawu. I-Tadalafil powder inceda ukuphumla i-prostate gland kunye ne-bladder ngaloo ndlela kunciphisa iimpawu ezihambelana ne-bladder kunye ne-urethra.

Unokunyanga kokubini ukungasebenzi kakuhle kwe-erectile kunye ne-benign prostatic hyperplasia

I-Tadalafil inokunceda amadoda aphethwe kukungasebenzi kakuhle kwe-erectile kunye nokwandiswa kwe-Prostate gland ngaxeshanye.
Xa usebenzisa i-tadalafil kumthamo olungileyo kwaye njengoko kucetyisiwe uvuna izibonelelo ezichaziweyo. Kuba ndonyusa ukuhamba kwegazi kwingingqi ye-penile nakwezinye iindawo, yindlela esempilweni yokujongana nezi meko.

Ingasetyenziselwa ukunyanga iimpawu zoxinzelelo lwegazi kwimiphunga

Uxinzelelo lwegazi lwe-pulmonary arterial (PAH) kuthetha ukuba kukho uxinzelelo lwegazi oluphezulu kwimithambo ethatha igazi lisuka entliziyweni liye emiphungeni. Kodwa yahlukile kuxinzelelo lwegazi oluqhelekileyo.
I-PAH yenzeka xa imithambo ebonelela ngegazi kwimiphunga iba mxinwa okanye ivalekile kukhokelela ekubeni intliziyo inyanzelwe ukuba ipompe igazi ngezinga eliphezulu. Oku kukhawuleza kunye nokunyanzelwa kwentliziyo kubangela uxinzelelo olukhulu kwimithambo.
I-Tadalafil powder iyamangalisa ngokuphumla kwemithambo yegazi. Oku kuphumla kuvumela ukuhamba kwegazi okuthe tye ngenxa yoko kunyusa izinga lokuhamba. Oku kunceda intliziyo ukuba impompe ukutyibilika kwegazi ngaloo ndlela isuse uxinzelelo oluya kuthi longezeleleke

Ukuphucula amandla akho omthambo

Ngexesha lokuhamba kwegazi kubalulekile ukuvumela umntu ukuba afumane i-oksijini eyaneleyo kunye nokuvelisa amandla aneleyo afunekayo.
I-Tadalafil inokunyusa ukusebenza kwakho ngokuzilolongela imithambo yegazi kunye nokunyusa ukuhamba kwegazi.

Iziphumo ebezingalindelekanga zeTadalafil

Iziphumo eziqhelekileyo ze-tadalafil zibandakanya;

  • Intloko ebuhlungu,
  • Isicaphucaphu,
  • ukucoca (ukufudumala, ubomvu, okanye ukuziva unomsindo),
  • isisu esiswini,
  • impumlo exineneyo okanye ebalekayo, kwaye
  • iintlungu zemisipha, iintlungu zomqolo, kunye neentlungu ezingalweni okanye emilenzeni.

I-Tadalafil inokukhokelela nakwimiphumo emibi kakhulu. Uyacetyiswa ukuba ufune uncedo lwezonyango ukuba ufumana naziphi na iziphumo ezilandelayo zetadalafil;

  • ezinye iimpawu zokuhlaselwa kwentliziyo kubandakanya iintlungu zesifuba, iintlungu zisasazeka emhlathini okanye egxalabeni, isicaphucaphu kunye nokubila.
  • utshintsho lombono kubandakanya ukungaboni kakuhle okanye ukulahleka kombono ngesiquphe.
  • ukucoca (ukufudumala, ubomvu, okanye ukuziva unomsindo),
  • Ukuva ukuphazamiseka kwi
  • ukukhala kwiindlebe zakho kunye nokulahleka kwendlebe
  • Ulwakhiwo olubuhlungu okanye oluhlala ixesha elide kuneeyure ezingama-4 njengoko oko kunokonakalisa ubudoda bakho.
  • Ukuvutha
  • Intliziyo engavumelekanga
  • Ukuphelelwa ngamandla, isiyezi kunye,
  • Ukudinwa okungaqhelekanga.

Ukusebenzisana kweziyobisi kweTadalafil

Unxibelelwano oluninzi lwe-tadalafil kunye nezinye iziyobisi zixeliwe. Ukudibana kweziyobisi kuhlala kuguqula umsebenzi wamayeza kwaye kunokubathintela ukuba basebenze ngokufanelekileyo.
Kucetyiswa kakhulu ukuba uxoxe ngamayeza akho ngaphambi kokuba usebenzise i-tadalafil. Olunye unxibelelwano lwe-tadalafil lunokuba nobulali kunye nolunye olubi.
Apha ngezantsi kukho unxibelelwano lwe-tadalafil;

Nitrates

Kukwabhekiswa kuzo njengeziyobisi zeAnguina. Xa i-nitrate ithathwa kunye ne-tadalafil, inokubangela ukuba uxinzelelo lwegazi luye kumanqanaba asezantsi kakhulu. Umgangatho ophantsi woxinzelelo lwegazi unxulunyaniswa neempawu ezinje ngesiyezi okanye nokudinwa.
Ezinye zezi ziyobisi zibuhlungu zibandakanya; I-butyl nitrite, i-amyl nitrite, isosorbide dinitrate, nitroglycerin, kunye ne-isosorbide mononitrate.

I-Alpha-blockers

La ngamachiza asetyenziselwa ukulungisa uxinzelelo lwegazi oluphezulu. Zikwasetyenziswa kunyango lweprostate. Zombini i-tadalafil kunye ne-alpha-blockers zii-vasodilator ezinefuthe lokunciphisa uxinzelelo lwegazi. Xa isetyenziswa kunye, inokubangela ukwehla okukhulu / okubalulekileyo kuxinzelelo lwegazi. Oku kubangela ukuba umntu abe nesiyezi kwaye angaphela amandla.
Ezinye zeziyobisi ze-alpha-blocker zibandakanya; terazosin, tamsulosin, alfuzosin, kunye neprazosin.

Ezinye iziyobisi ze-HIV

La machiza yi-protease inhibitors kwaye kungoko linokunyusa inqanaba le-tadalafil egazini. Olu konyuka lubangela uxinzelelo lwegazi olusezantsi. Inokubangela ukungakhathali emadodeni oko kuthetha ukuba bafumana ulwandiso olwandisiweyo oluhlala lubuhlungu.
Amanye ala machiza yi-ritonavir kunye ne-lopinavir.

Antibiotics

Ukudibana kweTadalafil kunye ne-antibiotics kuye kwaxelwa. Xa ithathiwe kunye ne-tadalafil, ii-antibiotics zinokunyusa inqanaba le-tadalafil egazini ekhokelela ekunciphiseni uxinzelelo lwegazi. Unokubangela isiyezi, ukuphelelwa ngamandla, kunye nemicimbi ethile yombono. Inokubangela nokukhathazeka emadodeni.
Amanye ala machiza yi-erythromycin, telithromycin, kunye ne-clarithromycin.
Nangona kunjalo, ii-antibiotics ezithile zingathoba amanqanaba e-tadalafil egazini. Olu nxibelelwano lwe-tadalafil alwenzi kakuhle. La machiza abandakanya; rifampin.

Iziyobisi ezichasayo

Ezinye iziyobisi ezichasayo zomlomo kubandakanya i-ketoconazole kunye ne-itraconazole inxibelelana ne-tadalafil.
Ezi ziyobisi zinokunyusa inqanaba le-tadalafil ekhokelela ekubeni nesiyezi kunye nokuphelelwa ngamandla kunokwenzeka.

Amanye amachiza oxinzelelo lwegazi kwimiphunga

I-Tadalafil kunye nezinye iziyobisi ze-pulmonary hypertension ziyaziwa ngokuba nefuthe lokunciphisa uxinzelelo lwegazi. Xa isetyenziswa kunye inokukhokelela kumanqanaba aphantsi oxinzelelo lwegazi. Oku kukhokelela kwiimpawu ezinxulumene noxinzelelo lwegazi ezinje ngesiyezi kunye nokuphelelwa ngamandla.
Amachiza abandakanya i-riociguat.

Iintsholongwane

La machiza asetyenziselwa ukunciphisa isisu esiswini. Xa zisetyenziswa ngokudibeneyo ne-tadalafil, zinokuthintela ukufunxwa kwe-tadalafil emzimbeni. Babandakanya i-magnesium hydroxide okanye i-aluminium hydroxide.

Amayeza okuxhuzula

Ezi zikwabizwa ngokuba ngamachiza okuthimba ukuhlutha. Xa uthatha iziyobisi ezichasene nokuthimba kunye ne-tadalafil, zinokuhlisa ukufunxwa kwe-tadalafil. Oku kuthetha ukuba i-tadalafil ayizukusebenza kakuhle. La machiza okuxhuzula aquka i-phenytoin, phenobarbital, kunye ne-carbamazepine.


Uyithenga phi iTadalafil?

Unokwenza iTadalafil ithenge kwiivenkile ezikwi-intanethi. Umgubo ufumaneka ngesixa esikhulu kubaphandi nakwabahlalutyi. Qiniseka ukuba ujonga i-tadalafil powder evunyiweyo yabanikezeli Xa ucinga ukuthatha i-tadalafil ithenge kubathengisi abathembekileyo.
Qhagamshelana nogqirha wakho ngaphambi kokuba uthathe i-tadalafil ngenxa yeempembelelo ze-tadalafil kunye nokusebenzisana kwe-tadalafil kunye nezinye iziyobisi.
Ukuba ujonga iTadalafil okanye abaphakathi, kuya kufuneka ungene kunye ne-CMOAPI ngonikezelo olusebenzayo lweemveliso ezisulungekileyo. Amakhompawundi ethu afumene isiqinisekiso somgangatho.


Ucaphulo
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